Which sign is associated with necrotizing disease in pancreatitis characterized by blue discoloration around the umbilicus?

The sign associated with necrotizing disease in pancreatitis that is characterized by blue discoloration around the umbilicus is indeed the Cullen sign. This discoloration typically indicates the presence of intra-abdominal bleeding, which can occur in severe cases of pancreatitis when there is pancreatic necrosis or hemorrhage. The appearance of the bluish color around the umbilicus results from blood tracking along the peritoneal pathways towards the abdominal wall.

In contrast, the Grey Turner sign refers to the blue discoloration that appears on the flanks, also indicating bleeding in the retroperitoneal space, but not specifically around the umbilicus. Charcot sign is related to triad symptoms of cholangitis (fever, jaundice, and right upper quadrant pain) and does not imply the same condition as the Cullen sign. McBurney sign indicates possible appendicitis and is assessed by pain in the right lower quadrant upon palpation. Each of these signs serves to identify different clinical conditions, reinforcing the importance of recognizing where each sign is localized and the underlying processes they may represent.