Which of the following symptoms is associated with Cushing's syndrome?

Truncal obesity is a classic symptom associated with Cushing's syndrome, which is characterized by excessive cortisol production in the body. This increased cortisol can lead to distinctive changes in body fat distribution, often resulting in a characteristic accumulation of fat in the trunk and face.

In addition to truncal obesity, patients with Cushing's syndrome may also exhibit features such as a rounded "moon face," a buffalo hump on the upper back, and thin extremities due to loss of muscle mass, further emphasizing the abnormal fat distribution associated with the condition.

The other symptoms listed do not align with Cushing's syndrome. For instance, weight loss is typically seen in conditions associated with inadequate cortisol levels or in catabolic states, and cold intolerance pertains to hypothyroid states rather than hypercortisolism. Constipation is also not a hallmark of Cushing's syndrome; in fact, patients may experience changes in bowel habits ranging from diarrhea to the opposite, depending on several factors including stress and diet. Thus, truncal obesity remains the most representative symptom of Cushing's syndrome.