Which of the following is a risk factor for gout?

Obesity is indeed a significant risk factor for gout. Gout occurs when there is an excess of uric acid in the body, leading to the formation of urate crystals in the joints, which causes inflammation and pain. Obesity contributes to increased production of uric acid and decreased renal clearance of urate, both of which can elevate uric acid levels in the bloodstream. Individuals with obesity are more likely to have metabolic syndrome, which is associated with insulin resistance and further exacerbates hyperuricemia, thereby increasing the risk of gout attacks.

While chronic kidney disease is also related to an increased risk of gout due to impaired uric acid excretion, it does not rank as high as obesity as a standalone risk factor in the general population. Asthma and osteoporosis are not known to have direct associations with the development of gout. Thus, among the options provided, obesity stands out as a well-established risk factor for this condition.