What type of disease is characterized by autosomal recessive inheritance leading to the production of hemoglobin S and causes vaso-occlusion?

The condition described is indeed consistent with sickle cell disease. This inherited disorder is caused by a mutation in the HBB gene, which encodes the beta-globin subunit of hemoglobin. The autosomal recessive inheritance pattern means that an individual must inherit two copies of the mutated gene (one from each parent) to manifest the disease.

In sickle cell disease, the mutation leads to the substitution of valine for glutamic acid at the sixth position of the beta-globin chain, resulting in the formation of hemoglobin S (HbS). When hemoglobin S deoxygenates, it polymerizes, causing red blood cells to assume a rigid, sickle shape. These sickled cells are less flexible and can obstruct small blood vessels, leading to vaso-occlusion. This vaso-occlusive crisis can result in acute pain episodes and various complications, including organ damage due to inadequate blood supply.

In terms of the other conditions listed, they do not share this autosomal recessive inheritance or the specific mechanism related to hemoglobin S and vaso-occlusion. Thrombotic thrombocytopenic purpura, for instance, is related to ADAMTS13 deficiency, leading to microangiopathic hemolytic anemia, but