What is the typical symptom of Sjogren syndrome?

Sjogren syndrome is characterized primarily by its impact on exocrine glands, leading to a profound reduction in glandular secretions. The hallmark symptoms of this autoimmune condition are dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia). The dryness occurs due to inflammation and damage to the salivary and lacrimal glands, impeding their ability to produce moisture, creating significant discomfort and difficulties in daily activities such as eating and seeing.

The other symptoms listed, such as proximal muscle weakness, inflammation of the synovium, and weight loss, are not central manifestations of Sjogren syndrome. Proximal muscle weakness may suggest other autoimmune or muscular disorders, while synovial inflammation is more closely associated with conditions like rheumatoid arthritis. Weight loss can occur in a variety of diseases but is not a typical feature of Sjogren syndrome itself, which primarily centers on glandular dysfunction leading to dryness symptoms. Thus, the combination of dry eyes and dry mouth distinctly identifies Sjogren syndrome, making it the correct answer.