What is the most common form of dementia that leads to severe dependency for ADLs over about 10 years?

Alzheimer's disease is recognized as the most prevalent form of dementia and is characterized by a progressive decline in cognitive function that ultimately leads to significant impairments in activities of daily living (ADLs). The course of Alzheimer's disease typically spans about 10 years, during which individuals may experience stages ranging from mild forgetfulness and confusion to severe memory loss and inability to perform basic self-care tasks.

This gradual deterioration occurs due to the accumulation of amyloid plaques and tau tangles in the brain, which disrupt communication between neurons and ultimately result in cell death. As the disease progresses, individuals often require increasing levels of assistance, making them increasingly dependent for activities such as bathing, dressing, and meal preparation.

Other dementias, while they may lead to dependency, differ in their patterns and timelines. For example, Lewy body dementia can also lead to significant disability but often presents with fluctuating cognition and parkinsonism, and has a different progression. Normal pressure hydrocephalus may present with gait changes and incontinence along with cognitive decline but is characterized by unique symptomatology and potentially reversible aspects if treated. Frontotemporal dementia often affects behavior and personality first, rather than cognitive function, and progresses differently compared to Alzheimer's.

Therefore, Alzheimer's disease