What is a common side effect of Niacin when used in dyslipidemia treatment?

Niacin, also known as vitamin B3, is used in the treatment of dyslipidemia primarily to lower LDL cholesterol and increase HDL cholesterol. One of the most notable side effects associated with Niacin is flushing, characterized by warmth, redness, and tingling of the skin, particularly in the face and upper body. This flushing response is attributed to the release of prostaglandins, which cause vasodilation and increased blood flow to the skin.

The incidence of flushing can be significant with Niacin therapy, and it often occurs shortly after the medication is taken. While various strategies, such as starting with a low dose or taking the medication with food or aspirin, can mitigate this effect, flushing remains a hallmark of Niacin therapy and is an important consideration when initiating treatment.

Other potential side effects of Niacin include gastrointestinal disturbances and, less commonly, liver toxicity, but the flushing response is the most frequently recognized and commonly discussed side effect, particularly in the context of dyslipidemia treatment.