What is a common side effect of Leflunomide?

Leflunomide is a disease-modifying antirheumatic drug (DMARD) commonly used in the treatment of rheumatoid arthritis. One of the notable side effects associated with Leflunomide is diarrhea. This gastrointestinal symptom can occur in a significant percentage of patients taking the medication. It is thought to result from Leflunomide's impact on the intestinal mucosa, contributing to its effect on cell turnover and immune modulation.

While nausea, dermatitis, and fatigue can also be associated with the use of Leflunomide, diarrhea stands out as more prevalent and noteworthy in clinical observations. Patients may experience varying degrees of gastrointestinal discomfort, leading to a temporary discontinuation of the drug in some cases, particularly if the diarrhea is severe. Understanding this common side effect is crucial for both patient management and counseling, emphasizing the need for healthcare providers to monitor gastrointestinal symptoms closely during treatment with Leflunomide.