Paget's disease of the bone primarily affects which areas of the body?

Paget's disease of bone is characterized by abnormal and excessive bone remodeling, which can lead to bone deformities and pain. This condition predominantly affects certain areas of the skeleton where bone turnover is typically high.

The pelvis, lumbar spine, and femur are particularly vulnerable due to their structural and functional importance in weight-bearing and movement. The pelvis is often the most commonly involved area, which may lead to hip pain or deformities; the lumbar spine can be affected, causing back pain or neurological symptoms due to spinal canal stenosis; and the femur can exhibit changes leading to bowing or fractures.

While other regions such as the skull and ribs do have reported involvement in Paget's disease, they are not as commonly affected or exhibit the same level of severity in terms of symptoms and complications compared to the pelvis, lumbar spine, and femur. Each of these areas from the correct answer is central to both mobility and stability in human anatomy, correlating with how Paget's disease presents clinically.