In acromegaly, which substance is measured due to unreliable GH measurement?

Enhance your knowledge with the Internal Medicine End of Rotation Exam. Challenge yourself with multiple-choice questions and detailed explanations to ensure you excel.

In acromegaly, measuring insulin-like growth factor 1 (IGF-1) is the preferred method for diagnosing the condition due to the unreliability of measuring growth hormone (GH) levels. In acromegaly, GH levels can be erratic, showing substantial variability throughout the day, influenced by factors such as stress, food intake, and diurnal rhythms. Consequently, a single measurement of GH may not accurately reflect the underlying abnormality.

IGF-1, on the other hand, remains more stable in the circulation. It is produced in response to GH and carries a long half-life, providing a more reliable indication of GH activity in the body over time. Elevated levels of IGF-1 are consistent in patients with acromegaly and provide a strong diagnostic marker for confirming the disorder. Hence, measuring IGF-1 is a crucial aspect in evaluating suspected cases of acromegaly.

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