Hodgkin lymphoma is characterized by which specific cells?

Hodgkin lymphoma is specifically characterized by the presence of Reed-Sternberg cells, which are abnormal, large cells found in the lymphatic tissue. These cells are derived from B lymphocytes and are considered a hallmark of the disease, aiding in its diagnosis. The identification of Reed-Sternberg cells is crucial because they help distinguish Hodgkin lymphoma from other types of lymphomas, as these cells have unique morphological features that set them apart.

In addition to their diagnostic significance, the presence of Reed-Sternberg cells also contributes to the pathophysiology of Hodgkin lymphoma, where they create an inflammatory microenvironment that is marked by a variety of immune responses. This understanding of the disease at a cellular level plays an essential role in tailoring effective treatment strategies.